Synthesis and coordination chemistry of 4??azabenzimidazole derivatives

MC Jahnke, D Brackemeyer, T Pape…

Index: Jahnke, Mareike C.; Brackemeyer, Dirk; Pape, Tania; Hahn, F. Ekkehardt Heteroatom Chemistry, 2011 , vol. 22, # 3-4 p. 476 - 490

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Citation Number: 9

Abstract

Abstract A facile method for the preparation of N1-(1a–6a) and N3-alkylated (1b–6b) 4- azabenzimidazole derivatives is presented. Both isomers were obtained by alkylation of 4- azabenzimidazole. The isomers were separated, and the preferred formation of the N1- alkylated derivatives (1a–6a) was observed. The C2-proton in the alkylated benzimidazoles can be exchanged for an iodine atom by treatment with methyl lithium and iodine, leading ...