Inhibition of adenosine 3', 5'-cyclic monophosphate phosphodiesterase by alkaloids. II.

T Ohmoto, T NIKAIDO, K KOIKE, K KOHDA…

Index: Ohmoto; Nikaido; Koike; Kohda; Sankawa Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4588 - 4592

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Citation Number: 38

Abstract

The structure-inhibitory activity relationships were studied in analogous alkaloids from Picrasma quassioides and Ailanthus altissima, and their derivatives. Altogether, 53β- carboline, 18 canthinone and 7 dimeric alkaloids were tested for cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibition. Major alkaloids (10, 63 and 74) among the three groups of congeners in Picrasma quassioides and Ailanthus altissima ...