Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

JJ Jablonski, D Basu, DA Engel, HM Geysen

Index: Jablonski, Joseph J.; Basu, Dipwanita; Engel, Daniel A.; Geysen, H. Mario Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 487 - 497

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Citation Number: 29

Abstract

Influenza is a continuing world-wide public health problem that causes significant morbidity and mortality during seasonal epidemics and sporadic pandemics. The existing vaccination program is variably effective from year to year, and drug resistance to available antivirals is a growing problem, making the development of additional antivirals an important challenge. Influenza virus non-structural protein 1 (NS1) is the centerpiece of the viral response to the ...