Tetrahedron letters

Synthesis of a 'reverse ester'analogue of 1, 2-sn-diglycerides from (S)-1, 2-di-O-isoprophylideneglycerol; efficient, stereospecific nucleophilic displacement via a triflate …

BT Golding, AL Griffin, DH Robinson

Index: Golding, Bernard T.; Griffin, Alice L.; Robinson, David H. Tetrahedron Letters, 1993 , vol. 34, # 40 p. 6459 - 6462

Full Text: HTML

Citation Number: 13

Abstract

Abstract An optically pure glyceride analogue in which the 2-O-ester grouping has been reversed was efficiently synthesised from (S)-di-O-isopropylideneglycerol by a sequence that featured an SN 2 displacement by the anion of diethyl malonate on a protected glycerol 2-O-triflate.