(Arylpiperazinyl) cyclohexylsufonamides: Discovery of α 1a/1d-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower …

…, S Li, PJ Connolly, V Pulito, J Liu, SA Middleton

Index: Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3292 - 3297

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Citation Number: 11

Abstract

Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS) can be effectively treated by α1-adrenergic receptor antagonists. Unfortunately, all currently marketed α1 blockers produced CV related side effects that are caused by the subtype non-selective nature of the drugs. To overcome this problem, it was postulated that a α1a/1d subtype selective antagonist would bring more benefit for the treatment of BPH/LUTS. In ...