Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT 1A partial agonists

AB Dounay, NS Barta, JA Bikker, SA Borosky…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 4 p. 1159 - 1163

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Citation Number: 7

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 2-aminopyrimidine 7, and diazotization in the presence of CuCl 2 yielded 2-chloropyrimidine 8. Although the conversion of 7–8 proceeded in modest yield, 8 was readily accessible on 100 g scale for use in medicinal chemistry studies ...