Synthesis and cytotoxic activity of 2-acyl-1H-indole-4, 7-diones on human cancer cell lines

S Mahboobi, A Sellmer, E Eichhorn, T Beckers…

Index: Mahboobi, Siavosh; Sellmer, Andreas; Eichhorn, Emerich; Beckers, Thomas; Fiebig, Heinz-Herbert; Kelter, Gerhard European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 85 - 92

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Citation Number: 16

Abstract

Synthesis and cytotoxic activity of a series of 2-acyl-1H-indole-4, 7-diones on human cancer cell lines are described. Due to close structural relationship to 2-acylindoles, potent inhibitors of tubulin polymerization, the mode of action of these novel compounds has been investigated. Cytotoxicity, the influence on tubulin polymerization, and cell cycle dependent cytotoxicity on colon carcinoma cells by investigation of RKO exo p27 versus RKO ...