Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies

…, M Wenz, JI Park, J Hasserodt, KD Janda

Index: Kim, Geun Tae; Wenz, Marion; Park, Jong Il; Hasserodt, Jens; Janda, Kim D Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1249 - 1262

Full Text: HTML

Citation Number: 12

Abstract

The synthesis of two tetraenes that differ in their methylation pattern from the natural substrate in lanosterol biosynthesis, 2, 3-oxidosqualene, and their examination with three catalytic antibodies is described. The design of these novel, linear terpenoid structures was governed by initial results obtained from the characterization of the three catalytic antibodies. These were generated by immunization with a steroidal hapten that mimics ...