Asymmetric synthesis of 1, 3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

…, SK Ahn, AJ Alves, JW Beach, LS Jeong…

Index: Kim, Hea O.; Ahn, Soon K.; Alves, Antonio J.; Beach, J. Warren; Jeong, Lak S.; et al Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 1987 - 1995

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Citation Number: 133

Abstract

In order to study the structureactivity relationships of dioxolane nucleosides as potential anti- HIV agents, various enantiomerically pure dioxolane-pyrimidine nucleosides have been synthesized and evaluated against HIV-1 in human peripheral blood mononuclear cells. The enantiomerically pure key intermediate 8 has been synthesized in nine steps from 1, 6- anhydro-~-mannose (l), which was condensed with 5-substituted pyrimidines to obtain ...