Tetrahedron

One-pot synthesis of 1, 5-diketones catalyzed by barium isopropoxide

A Yanagisawa, H Takahashi, T Arai

Index: Yanagisawa, Akira; Takahashi, Hiroshi; Arai, Takayoshi Tetrahedron, 2007 , vol. 63, # 35 p. 8581 - 8585

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Citation Number: 19

Abstract

A tandem cross-coupling reaction of aryl methyl ketones with aromatic aldehydes has been accomplished employing barium isopropoxide as a catalyst, in which barium enolates are generated and then three consecutive reactions (aldol reaction/β-elimination/conjugate addition) occur; this one-pot procedure is a convenient method to obtain symmetrical 1, 5- diketones in good yields. In some cases, addition of iso-propanol is effective in improving ...

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