Phase transfer catalyzed synthesis of bis-quinolines: antileishmanial activity in experimental visceral leishmaniasis and in vitro antibacterial evaluation

P Palit, P Paira, A Hazra, S Banerjee, AD Gupta…

Index: Palit, Partha; Paira, Priyankar; Hazra, Abhijit; Banerjee, Sukdeb; Gupta, Asish Das; Dastidar, Sujata G.; Mondal, Nirup B. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 845 - 853

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Citation Number: 43

Abstract

A one-pot synthesis of some novel bis-quinolines has been achieved under phase transfer catalyzed conditions using 8-hydroxy quinoline derivatives as substrates. The synthesized analogues were evaluated for antileishmanial activity against Leishmania donovani promastigotes and amastigotes. The entire bis-quinolines showed efficacy in both in vitro and in vivo studies. Compound 5 (1, 1-bis-[(5-chloro-8-quinolyl) oxy] methane) exhibited ...