Direct Formation of 2, 3, 5??Trichloropyridine and its Nucleophilic Displacement Reactions in Ionic Liquid

P Zhong, H Hu, S Guo

Index: Zhong, Ping; Hu, Huanan; Guo, Shengrong Synthetic Communications, 2004 , vol. 34, # 23 p. 4301 - 4311

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Citation Number: 11

Abstract

Abstract Reaction of trichloroacetaldehyde and acrylonitrile in the presence of a catalytic amount of copper (I) chloride in ionic liquid afforded 2, 3, 5??trichloropyridine, fluorination of which with KF and CsF in ionic liquid afforded 3, 5??dichloro??2??fluoropyridine and 5??chloro?? 2, 3??dichloropyridine. Reaction of 2, 3, 5??trichloropyridine, 3, 5??dichloro??2??fluoropyridine, or 5??chloro??2, 3??dichloropyride with 2??(4??hydroxyphenoxy) propionates in ionic liquid ...