Synlett

Synthesis of Allenic (α, α-Difluoromethylene) phosphonates from Propargylic Tosylates and Acetates

T Yokomatsu, A Ichimura, J Kato, S Shibuya

Index: Yokomatsu; Ichimura; Kato; Shibuya Synlett, 2001 , # 2 p. 287 - 289

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Citation Number: 8

Abstract

Abstract: Copper (I) bromide-promoted reactions of bromo [(diethoxyphosphoryl) difluoromethyl] zinc reagent 2 with propargylic tosylates and acetates were examined. The reaction proceeded in an SN2'manner to give allenic (a, a-difluoromethylene) phosphonates in good to excellent yield. Key words: allenes, addition reaction, organometallic reagents, phosphate mimics, fluorine (a, a-Difluoromethylene) phosphonic acids (DFMPA) as ...