A General Synthetic Entry to Strychnos Alkaloids of the Curan Type via a Common 3a-(2-Nitrophenyl) hexahydroindol-4-one Intermediate. Total Syntheses of (±)-and ( …

J Bonjoch, D Solé, S García-Rubio…

Index: Sole, Daniel; Garcia-Rubio, Silvina; Bosch, Joan; Bonjoch, Josep Heterocycles, 1996 , vol. 43, # 11 p. 2415 - 2424

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Citation Number: 87

Abstract

A general strategy for the synthesis of pentacyclic Strychnos alkaloids with the curan skeleton has been developed. It utilizes 3a-(2-nitrophenyl) hexahydroindol-4-one (23), which was prepared from 2-allyl-2-(2-nitrophenyl)-1, 3-cyclohexanedione (15), as the