Synthesis and DNA Polymerase. ALPHA. and. BETA. Inhibitory Activity of Alkyl p-Coumarates and Related Compounds

…, Y Takenaka, M Kishi, T Tanahashi, H Yoshida…

Index: Nishimura, Katsumi; Takenaka, Yukiko; Kishi, Manami; Tanahashi, Takao; Yoshida, Hiromi; Okuda, Chiaki; Mizushina, Yoshiyuki Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 5 p. 476 - 480

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Citation Number: 15

Abstract

trans-and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases α and β. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases α and β.