Novel tetracyclic spiropiperidines. 3. 1-Arylspiro [indoline-3, 4'-piperidine] s as potential antidepressants

…, JA Profitt, J Fortunato, EJ Glamkowski…

Index: Ong; Profitt; Fortunato; Glamkowski; Ellis; Geyer; Wilker; Burghard Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 981 - 986

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Citation Number: 15

Abstract

A series of l-arylspiro [indoline-3, 4'-piperidine] s was synthesized and evaluated for potential antidepressant activity by tetrabenazine (TBZ) ptosis prevention and potentiation of 5-hydroxytryptophan (5-HTP) induced head twitching in pargyline-pretreated rats. Marked TBZ activity was observed with analogues bearing an ortho substituent on the pendant aromatic ring, as exemplified by lead compound 25a, l-(2-chlorophenyl) spiro [indoline-3, ...