Ligand??Free??Palladium??Catalyzed Direct 4??Arylation of Isoxazoles Using Aryl Bromides

…, C Reynaud, H Doucet, M Santelli

Index: Fall, Yacoub; Reynaud, Celine; Doucet, Henri; Santelli, Maurice European Journal of Organic Chemistry, 2009 , # 24 p. 4041 - 4050

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Citation Number: 21

Abstract

Abstract 4-Arylisoxazoles can be easily prepared by a palladium-catalysed C–H bond activation/arylation of 3, 5-disubstituted isoxazoles using aryl or heteroaryl bromides. Good yields were generally obtained by using 0.1–0.5 mol-% of the air-stable PdCl 2 complex as the catalyst. A range of functional groups such as acetyl, formyl, ester, fluoro, nitro, trifluoromethyl or nitrile on the aryl bromide is tolerated. This reaction is environmentally ...