Bioorganic & medicinal chemistry letters

Heterocyclic nucleoside analogues: design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles

YS Lee, BH Kim

Index: Lee, Yoon-Suk; Byeang, Hyean Kim Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1395 - 1397

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Citation Number: 92

Abstract

We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis).