. beta.-Lactam analogs of oxotremorine. 3-and 4-Methyl-substituted 2-azetidinones

BM Nilsson, B Ringdahl, U Hacksell

Index: Nilsson, Bjoern M.; Ringdahl, Bjoern; Hacksell, Uli Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 580 - 584

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Citation Number: 54

Abstract

Four@-lactam analogues (8-1 1) of oxotremorine were synthesized and assayed for muscarinic and antimuscarinic activity on the isolated guinea pig ileum. The pharmacological resulta were compared with those obtained previously with the@-lactam analogue 7 and the 3-, 4-, and 5-methyl-substituted 2-pyrrolidones 2-6. The new compounds were less potent than the corresponding 2-pyrrolidones, regardless of whether they ...