Direct Hydrosilylation of Tertiary Amides to Amines by an In Situ Formed Iron/N??Heterocyclic Carbene Catalyst

…, E Buitrago, H Adolfsson

Index: Volkov, Alexey; Buitrago, Elina; Adolfsson, Hans European Journal of Organic Chemistry, 2013 , # 11 p. 2066 - 2070

Full Text: HTML

Citation Number: 21

Abstract

Abstract Tertiary amides were efficiently reduced to their corresponding tertiary amines in high isolated yields by using the commercially available and inexpensive polymeric silane polymethylhydrosiloxane (PMHS) as the reducing agent. The reaction is efficiently catalyzed by an in situ generated iron/N-heterocyclic carbene complex (1 mol-%) obtained from iron (II) acetate and 1-(2-hydroxy-2-phenylethyl)-3-methylimidazolium triflate ([PhHEMIM][OTF] ...