Structural evolution and pharmacology of a novel series of triacid angiotensin II receptor antagonists

AD Palkowitz, MI Steinberg, KJ Thrasher…

Index: Palkowitz, Alan D.; Steinberg, Mitchell I.; Thrasher, K. Jeff; Reel, Jon K.; Hauser, Kenneth L.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 26 p. 4508 - 4521

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Citation Number: 40

Abstract

cis-4-(4-Phenoxy)-l-[l-oxo-2 (R)-[4-[(2-sulfobenzoyl) amino)-~-imidazol-l-ylloctyll-~-proline derivatives represent a novel class of potent nonpeptide angiotensin I1 (Ang 11) receptor antagonists. These compounds evolved from directed structure-activity relationship (SAR) studies on a lead identified by random screening. Further SAR studies revealed that acidic modification of the 4-phenoxy ring system produced a series of triacid derivatives ...