Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

KV Butler, J Kalin, C Brochier, G Vistoli…

Index: Journal of the American Chemical Society, , vol. 132, # 31 p. 10842 - 10846

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Citation Number: 265

Abstract

... Journal of the ... 2010, 132 (31), pp 10842–10846. DOI: 10.1021/ja102758v. Publication Date (Web): July 9, 2010. Copyright © 2010 American Chemical Society. ... drug target.(7) Tubacin, an HDAC6 selective inhibitor, was identified in 2003 by combinatorial chemistry methods.(20 ...