Carboxyl-modified amino acids and peptides as protease inhibitors
SA Thompson, PR Andrews…
Index: Thompson, Stewart A.; Andrews, Peter R.; Hanzlik, Robert P. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 104 - 111
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Citation Number: 96
Abstract
Design Our purpose was to evaluate the inhibitory potential of functional groups incorporated into substrate analogues by testing them against proteases representing several different classes, while at the same time minimizing the amount of swthesis required. To meet this objective we selected five primary target enzymes which were commercially available and well characterized:(1) chymotrypsin (CT), a serine endoprotease preferring ...
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