Carbohydrate research

En route to deoxygenated N-acetyllactosamine analogues employing uridyl and galactosyl transferases

D Lazarevic, H Streicher, J Thiem

Index: Lazarevic, Daniel; Streicher, Harald; Thiem, Joachim Carbohydrate Research, 2009 , vol. 344, # 12 p. 1449 - 1452

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Abstract

All monodeoxygenated galactoses were treated with galactokinase, and for the 2-, 3-, and 4- deoxy compounds, transformation into the corresponding galactopyranosyl phosphates could be observed. In case of the 2-deoxy derivative, further reaction via UDP-2-deoxy-d- lyxo-hexose (UDP-2-deoxygalactose), which was also obtained chemically, the multiple enzymatic system could be employed to prepare 2′-deoxy-N-acetyllactosamine.