(.+-.)-N9-(2-(Hydroxymethyl) spiro [3.3] hept-6-yl) adenine. The First Biologically Active Saturated Analog of Adenallene with Axial Dissymmetry

…, TH Corbett, D Kessel, J Zemlicka

Index: Jones; Drach; Corbett; Kessel; Zemlicka Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6277 - 6280

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Citation Number: 9

Abstract

12 noesterification12 of terephthalic acid with NJV-dimethylformamide dimethyl acetal on an analytical scale. Reaction of acid 3 (1 mmol) in DMF with a 3-fold molar excess of NJV- dimethylformamide dimethyl acetal in DMF gave monoester 4 (52%) in addition to diester 5 (17%, Scheme 1). When the scale was expanded to 16 mmol of 3, the extent of formation of diester 5 (37%) approximately equaled that of monoester 4 (34%). At any rate, a sufficient ...