Concise synthesis of highly substituted benzo [a] quinolizines by a multicomponent reaction/allylation/Heck reaction sequence

…, DLJ Broere, E Janssen, FJJ de Kanter…

Index: Den Heeten, Rene; Van Der Boon, Leon J. P.; Broere, Daniel L. J.; Janssen, Elwin; De Kanter, Frans J. J.; Ruijter, Eelco; Orru, Romano V. A. European Journal of Organic Chemistry, 2012 , # 2 p. 275 - 280

Full Text: HTML

Citation Number: 6

Abstract

Abstract The combination of the recently developed multicomponent construction of highly substituted 3, 4-dihydropyridones with subsequent allylation and intramolecular Heck-type cyclization allows the straightforward construction of benzo [a] quinolizines, a class of polycyclic compounds that–despite their interesting pharmacological and photochemical properties–have little precedent in the literature. After optimization of the individual steps, ...