Chemical Communications

Fluorination reactions in microreactors

T Gustafsson, R Gilmour, PH Seeberger

Index: Gustafsson, Tomas; Gilmour, Ryan; Seeberger, Peter H. Chemical Communications, 2008 , # 26 p. 3022 - 3024

Full Text: HTML

Citation Number: 31

Abstract

In order to establish general deoxyfluorination conditions, exploratory reactions were performed in toluene, dichloromethane and tetrahydrofuran. Dichloromethane was quickly identified as being the solvent of choice. Furthermore, the incorporation of a 75 psi HPLC back pressure regulator allowed the solvent to be super-heated to 70 °C resulting in shortened reaction times. 10 For economic reasons it was deemed prudent to use exactly 1 equivalent of DAST in the ...