Control of 6??Exo and 7??Endo Cyclizations of Alkynylamides using Platinum and Bismuth Catalysts

…, S Yokouchi, C Tsukano, Y Takemoto

Index: Girard, Anne-Lise; Enomoto, Taro; Yokouchi, Shinsuke; Tsukano, Chihiro; Takemoto, Yoshiji Chemistry - An Asian Journal, 2011 , vol. 6, # 6 p. 1321 - 1324

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Citation Number: 19

Abstract

Piperazin-2-one and 1, 4-diazepan-2-one scaffolds are featured in biologically active natural products and pharmaceutical compounds,[1] such as peptidomimetics,[2] compounds with potential to reverse multi-drug resistance in cancer treatments (ardeemins),[3] antibiotics (caprazamicins),[4] sedatives, and tranquilizers (diazepam)[5]. These structures have therefore attracted considerable attention as important pharmacophores in the field of ...