Synthesis and cyclization of dialkylmalonuric esters

JA Beres, MG Varner, C Bria

Index: Beres; Varner; Bria Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 4 p. 451 - 454

Full Text: HTML

Citation Number: 0

Abstract

Abstract A novel method for the synthesis of methyl dialkylmalonuric esters was developed using the base-catalyzed ring opening of an isopropylidene malonic ester with urea as the key step. The rates of cyclization of these malonuric esters to the corresponding barbituric