Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx

M Kimura, T Wakimoto, Y Egami, KC Tan…

Index: Kimura, Miki; Wakimoto, Toshiyuki; Egami, Yoko; Tan, Karen Co; Ise, Yuji; Abe, Ikuro Journal of Natural Products, 2012 , vol. 75, # 2 p. 290 - 294

Full Text: HTML

Citation Number: 28

Abstract

Cyclic peptides containing 5-hydroxytryptophan and thiazole moieties were isolated from the marine sponge Discodermia calyx collected near Shikine-jima Island, Japan. The structures of calyxamides A (1) and B (2), including the absolute configurations of all amino acids, were elucidated by spectroscopic analyses and degradation experiments. The structures are similar to keramamides F and G, previously isolated from Theonella sp. The analysis of ...