Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking …

MO Hamad, PK Kiptoo, AL Stinchcomb…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 7051 - 7061

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Citation Number: 42

Abstract

... Bioorganic & Medicinal Chemistry. ... careful design of the codrug entity can afford a unique product that may have superior physicochemical properties for drug delivery, compared to those of the individual drug entities themselves, leading to improved pharmaceutical properties. ...