Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (−)??Biyouyanagin A

C Du, L Li, Y Li, Z Xie

Index: Du, Chao; Li, Liqi; Li, Ying; Xie, Zhixiang Angewandte Chemie - International Edition, 2009 , vol. 48, # 42 p. 7853 - 7856

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Citation Number: 40

Abstract

The motif of two vicinal quaternary carbon centers is found in a wide range of bioactive natural products such as hyperolactones A–C [1] and (À)-biyouyanagin A [2](Scheme 1). The interesting biological activities and unique structures of these compounds have stimulated many total syntheses.[3] In general, the stereoselective construction of two vicinal quaternary carbon centers relys on substrate control. Only a few catalytic asymmetric CÀC ...