The synthesis of fragment a of an antibiotic, nosiheptide
…, H Noda, J Yoshimura, A Konn, Y Yonezawa, C Shin
Index: Umemura, Kazuyuki; Noda, Hirofumi; Yoshimura, Juji; Konn, Akihito; Yonezawa, Yasuchika; Shin, Chung-Gi Tetrahedron Letters, 1997 , vol. 38, # 20 p. 3539 - 3542
Full Text: HTML
Citation Number: 34
Abstract
Fragment A derivative (13) of nosiheptide, useful for the total synthesis, was obtained by stepwise introduction of the 2, 5-bis {(4-ethoxycarbonyl)-2-thiazolyl} groups and 6-{(2- substituted)-4-thiazolyl} group into 3-hydroxy-5-cyanopyridine (3). The total yield was 7.6% via 14 steps.
Related Articles:
Synthesis of a Fragment A Derivative of an Antibiotic, Nosiheptide.
[Umemura, Kazuyuki; Noda, Hirofumi; Yoshimura, Juji; Konn, Akihito; Yonezawa, Yasuchika; Shin, Chung-Gi Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 6 p. 1391 - 1396]