Synthesis of licochalcone analogues with increased anti-inflammatory activity

SJ Kim, CG Kim, SR Yun, JK Kim, JG Jun

Index: Kim, Si-Jun; Kim, Cheol Gi; Yun, So-Ra; Kim, Jin-Kyung; Jun, Jong-Gab Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 181 - 185

Full Text: HTML

Citation Number: 13

Abstract

Abstract Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1– 6) thus prepared are compared for their suppression ability of nitric oxide (NO) production ...