Journal of the American Chemical Society

Some 5-substituted aminouracils

AP Phillips

Index: Phillips Journal of the American Chemical Society, 1951 , vol. 73, p. 1061

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Citation Number: 13

Abstract

Although the high reactivity for replacement reactions of pyrimidines bearing a 2, 4-or 6- chloro group is well known, little has been done with halogen in the 5-position. Previously 5- bromouracil has been treated only with ammoniaa and di~ nethylamine,~~~~~ both reactions having been carried out in a sealed tube at 150-180. Moreover, Lythgoe5 and Johnsons both state that replacing chlorine or bromine in the 5-position by ammonia is a ...