Electrostatic effects on ion selectivity and rectification in designed ion channel peptides

JD Lear, JP Schneider, PK Kienker…

Index: Lear; Schneider; Kienker; DeGrado Journal of the American Chemical Society, 1997 , vol. 119, # 14 p. 3212 - 3217

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Citation Number: 75

Abstract

To help determine how amino acid sequence can influence ionic conduction properties in α- helical structures, we have synthesized and studied three closely related, channel-forming peptides. The sequences are based on a 21-residue amphiphilic Leu-Ser-Ser-Leu-Leu-Ser- Leu heptad repeat motif and differ in having either neutral, negatively, or positively charged N-termini. The channels formed by the neutral peptide are modestly cation selective and ...