Synthesis and radioprotective activity of new N-(amino acid)-S-acetylcysteamine and cystamine derivatives

…, JY Pue, M Fatome, H Sentenac-Roumanou…

Index: Oiry; Pue; Fatome; Sentenac-Roumanou; Lion; Imbach European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 809 - 817

Full Text: HTML

Citation Number: 7

Abstract

Abstract In order to evaluate the influence of an amino acid conjugation (Sar, Ser, Phe, Pro, Thz) on S-acetylcysteamine, cystamine, N-(amino acid)-S-acetylcysteamine (14–18) and N, N′-bis (amino acid) cystamine (24–28) derivatives have been synthesized and evaluated as potential radioprotectors. Their toxicity and radioprotective activity, as the dose reduction factor (DRF) have been determined (in vivo; ip) and compared with cysteamine and ...