Synthesis of 4??hydroxy??3??triftuoromethylpyrazoles

…, J Namekata, K Tanaka, K Mitsuhashi

Index: Iwata, Satoru; Namekata, Junji; Tanaka, Kiyoshi; Mitsuhashi, Keiryo Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 8 p. 1971 - 1976

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Citation Number: 8

Abstract

Abstract Trifluoroacetaldehyde hydrazones are condensed with glyoxals to give 4-hydroxy-3- trifluoromethylpyrazoles, the reaction offering a novel route to 4-hydroxypyrazoles carrying trifluoromethyl group. The 4-hydroxyl group was easily converted to its derivatives by the reaction with various electrophiles.