Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

N Charrier, B Clarke, L Cutler, E Demont…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 13 p. 3674 - 3678

Full Text: HTML

Citation Number: 41

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The chemical space in which compounds with an acceptable lipophilicity profile (1 < Log D < 3) are predicted to be well absorbed is now populated, in contrast to the predictions for our first generation sultams. ...