Easy oxidation and nitration of human myoglobin by nitrite and hydrogen peroxide

…, E Monzani, AM Sanangelantoni…

Index: Nicolis, Stefania; Pennati, Andrea; Perani, Eleonora; Monzani, Enrico; Sanangelantoni, Anna Maria; Casella, Luigi Chemistry - A European Journal, 2006 , vol. 12, # 3 p. 749 - 757

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Citation Number: 34

Abstract

Abstract The modification of human myoglobin (HMb) by reaction with nitrite and hydrogen peroxide has been investigated. This reaction is important because NO 2− and H 2 O 2 are formed in vivo under conditions of oxidative and nitrative stress, where protein derivatization has been often observed. The abundance of HMb in tissues and in the heart makes it a potential source and target of reactive species generated in the body. The oxidant and ...