Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K

JT Palmer, C Bryant, DX Wang, DE Davis…

Index: Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7520 - 7534

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Citation Number: 92

Abstract

... Journal of Medicinal Chemistry. ... Point, Pennsylvania. J. Med. Chem. , 2005, 48 (24), pp 7520–7534. DOI: 10.1021/jm058198r. Publication Date (Web): October 29, 2005. Copyright © 2005 American Chemical Society. ...

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Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K

[Palmer, James T.; Bryant, Clifford; Wang, Dan-Xiong; Davis, Dana E.; Setti, Eduardo L.; Rydzewski, Robert M.; Venkatraman, Shankar; Tian, Zong-Qiang; Burrill, Leland C.; Mendonca, Rohan V.; Springman, Eric; McCarter, John; Chung, Tobee; Cheung, Harry; Janc, James W.; McGrath, Mary; Somoza, John R.; Enriquez, Philip; Yu, Z. Walter; Strickley, Robert M.; Liu, Liang; Venuti, Michael C.; Percival, M. David; Falgueyret, Jean-Pierre; Prasit, Peppi; Oballa, Renata; Riendeau, Denis; Young, Robert N.; Wesolowski, Gregg; Rodan, Sevgi B.; Johnson, Colena; Kimmel, Donald B.; Rodan, Gideon Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7520 - 7534]

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