Neopentyl 3-triflyloxypropanesulfonate. A reactive sulfopropylation reagent for the preparation of chemiluminescent labels

M Adamczyk, YY Chen, PG Mattingly…

Index: Adamczyk, Maciej; Chen, Yon-Yih; Mattingly, Phillip G.; Pan, You; Rege, Sushil Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5636 - 5639

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Citation Number: 55

Abstract

Chemiluminescent acridinium salts by virtue of their high quantum efficiency can be detected at the attomole (10-18 mol) level and below1 and thus have recently been used as labeling reagents for ultrasensitive clinical assays. 2 The N10-methyl derivatives have generally been employed and are efficiently prepared by quarternization of the acridine precursor with methyl fluorosulfate or methyl triflate; poor conversion is seen with ...