Tetrahedron Letters

A new synthesis of sultams from amino alcohols

N Lad, R Sharma, VE Marquez, M Mascarenhas

Index: Lad, Nitin; Sharma, Rajiv; Marquez, Victor E.; Mascarenhas, Malcolm Tetrahedron Letters, 2013 , vol. 54, # 47 p. 6307 - 6309

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Abstract

Cyclic sulfonamides (sultams 1 ), although not found in nature, are present in a number of biologically active compounds. They are known to display a variety of pharmacological effects such as cardioprotective, 2 lipoprotein disorders, 3 anti-psychotic, 4 and antifungal. 5 They also have found application as LTB4 inhibitors for allergy and asthma treatment, 6 cyclooxygenase-2 inhibitors for anti-arthritic activity, 7 elastase inhibitors as oncolytics, 8 and antibacterial. 9 A number ...