Domino Heck–Aza??Michael Reactions: A One??Pot, Sequential Three??Component Approach to 1, 1??Dioxido??1, 2??benzisothiazoline??3??acetic Acid

A Rolfe, K Young, PR Hanson

Index: Rolfe, Alan; Young, Kyle; Hanson, Paul R. European Journal of Organic Chemistry, 2008 , # 31 p. 5254 - 5262

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Citation Number: 26

Abstract

Abstract The development of a new method for the synthesis of 1, 1-dioxido-1, 2- benzisothiazoline-3-acetic acid by a domino process is reported whereby a classical Heck reaction is coupled to an intramolecular aza-Michael reaction. Ultimately, this method has been expanded to a one-pot, sequential three-component protocol to generate diverse benzofused γ-sultams from a range of commercially available α-bromobenzenesulfonyl ...