Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase α

…, D Sandovski, A Elgart, E Alpert, G Cohen…

Index: Gruzman, Arie; Shamni, Ofer; Yakir, Moriya Ben; Sandovski, Daphna; Elgart, Anna; Alpert, Evgenia; Cohen, Guy; Hoffman, Amnon; Katzhendler, Yehoshua; Cerasi, Erol; Sasson, Shlomo Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8096 - 8108

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Citation Number: 26

Abstract

Type 2 diabetes mellitus has reached epidemic proportions; therefore, the search for novel antihyperglycemic drugs is intense. We have discovered that d-xylose increases the rate of glucose transport in a non-insulin-dependent manner in rat and human myotubes in vitro. Due to the unfavorable pharmacokinetic properties of d-xylose we aimed at synthesizing active derivatives with improved parameters. Quantitative structure− activity relationship ...