Efficient synthesis of 2′-amino-2′-deoxypyrimidine 5′-triphosphates

…, C Vargeese, Y Zhai, GP Kirschenheuter…

Index: McGee; Vargeese; Zhai; Kirschenheuter; Settle; Siedem; Pieken Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1329 - 1339

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Citation Number: 23

Abstract

Abstract The synthesis of 2′-amino-2′-deoxypyrimidine 5′-triphosphates is described. The 2′-amino-2′-deoxyuridine 5′-triphosphate is obtained from uridine in four steps with 25% overall yield. The 2′-amino-2′-deoxycytidine 5′-triphosphate is obtained from uridine in seven steps with 13% overall yield.