Small molecule mimetics of an interferon-α receptor interacting domain

…, L Wei, B Majchrzak-Kita, N Salum, MK Purohit…

Index: Bello, Angelica M.; Wei, Lianhu; Majchrzak-Kita, Beata; Salum, Norue; Purohit, Meena K.; Fish, Eleanor N.; Kotra, Lakshmi P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 978 - 985

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Citation Number: 2

Abstract

Abstract Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distinct chemotypes, containing the molecular features represented by the key residues Leu30, Arg33, and Asp35 in IRRP-1. Three of these compounds exhibited potential mimicry to ...