… evaluation of N-(4-methoxy-1 H-benzo [d] imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1 H-benzo [d] imidazol)-7-sulfonamide analogs of combretastatin A-4

J Zhou, Y Zhang, YW Cui, ZM Li, HR Song…

Index: Zhou, Jie; Zhang, Yi; Cui, Yi-Wen; Li, Zhan-Mei; Song, Hong-Rui; Dong, Jin-Hua; Chen, Xiao-Guang; Xu, Bai-Ling Journal of Asian Natural Products Research, 2011 , vol. 13, # 4 p. 330 - 340

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Abstract

Two series of novel benzoimidazole sulfonamides as combretastatin A-4 analogs were synthesized. The cytotoxicities of the title compounds were evaluated against five different cancer cell lines. Among the tested compounds, four compounds displayed cytotoxicities against the HCT8 cell line. Compound 6a has shown the strongest potency against the tested human tumor cell lines with an IC50 value ranging from submicromolar to ...