Synthesis and characterization of adducts of alachlor and 2-chloro-N-(2, 6-diethylphenyl) acetamide with 2'-deoxyguanosine, thymidine, and their 3'-monophosphates

…, GR Lambert, P Boone, AM Richard

Index: Nesnow, Stephen; Agarwal, Satish C.; Padgett, William T.; Lambert, Guy R.; Boone, Phillip; Richard, Ann M. Chemical Research in Toxicology, 1995 , vol. 8, # 2 p. 209 - 217

Full Text: HTML

Citation Number: 13

Abstract

CDEPA with 2'-deoxyguanosine 3'-monophosphate and N-3 adducts with thymidine 3'- monophosphate are also described. In addition to spectroscopic data, structural proof included the dephosphorylation of each nucleotide adduct to its corresponding nucleoside adduct by nuclease P1. Alachlor and alachlor adducts but not CDEPA and CDEPA adducts exhibited rotational isomerism as evidenced by proton and 13C NMR studies. These ...