Tetrahedron Letters

Synthesis of unit-B of cryptophycin-24 via Sharpless asymmetric dihydroxylation

AJ Borah, P Goswami, NC Barua, P Phukan

Index: Borah, Arun Jyoti; Goswami, Progyashree; Barua, Nabin C.; Phukan, Prodeep Tetrahedron Letters, 2012 ,  vol. 53,  # 52  p. 7128 - 7130

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Citation Number: 5

Abstract

A synthetic pathway for the synthesis of unit-B of cryptophycin-24 has been developed using Sharpless asymmetric dihydroxylation as the key step. This study shows that direct azidation of α-hydroxy acid ester using diphenylphosphoryl azide is beneficial to asymmetric synthesis of α-amino acid without the loss of chirality during the transformation.